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Life Sciences - Pharmacology - 29.09.2023 
Combating Multidrug-Resistant Bacteria through High-Resolution Structural Imaging
A European research team led by the Department of Chemistry at Universität Hamburg presents a study showing high-resolution structures of 17 distinct antibiotic ribosomal compounds. The knowledge could pave the way for the development of new antibiotics to combat multidrug-resistant bacteria. The results were published in the journal Nature Structural & Molecular Biology.
Pharmacology - Career - 27.09.2023 
How a suction cup delivers medications to the bloodstream
Researchers at ETH Zurich have developed a suction cup that allows medications to be absorbed through the mucosal lining of the cheeks. This new approach could spare millions of patients the pain and fear associated with injections. Many of today's medications belong to groups of relatively large molecules such as peptides.
Health - Pharmacology - 27.09.2023
Health - Pharmacology - 27.09.2023
Health - Pharmacology - 26.09.2023 
Key improvement to Nobel Prize-winning technology
An advance in cryo-EM could be a significant boon for research on potential cancer therapies Science + Technology An advance in cryo-EM could be a significant boon for research on potential cancer therapies September 26, 2023 Key takeaways A technology called cryo-electron microscopy, or cryo-EM, enables scientists to see the atomic structure of biological molecules in high resolution.
Health - Pharmacology - 26.09.2023 
Fluorescence gives doctors a real-time connection with the health of the gut
Imperial and US medical technology company MediBeacon have partnered to advance a non-invasive method of assessing intestinal health. In healthy people, the wall of the intestine forms a barrier between the contents of the gut and the rest of the body, with only the nutrients produced by digestion passing through.
Health - Pharmacology - 25.09.2023
Health - Pharmacology - 25.09.2023 
Widely-used COVID-19 antiviral could be helping SARS-CoV-2 to evolve
Molnupiravir, an antiviral drug used to treat patients with COVID-19, appears to be driving SARS-CoV-2 to mutate and evolve, with some of these new viruses being transmitted onwards, a new study has shown. It is not clear, however, whether these mutated viruses pose an increased risk to patients or are able to evade the vaccine.
Life Sciences - Pharmacology - 25.09.2023
Health - Pharmacology - 25.09.2023 
Could hydrogel make HIV therapy more convenient?
Could this new hydrogel make HIV therapy more convenient? A new injectable solution that self-assembles into a gel under the right conditions could help manage HIV unlike any currently available methods, Johns Hopkins researchers have found A new injectable solution that self-assembles into a gel under the right conditions could help manage HIV unlike any currently available methods, researchers have found.
Pharmacology - Health - 22.09.2023 
AI model aims to predict how medicines taste
A team from the UCL Global Business School for Health (GBSH) and the UCL School of Pharmacy are using data collected from an "electric tongue" to create an AI model for predicting the bitterness of drugs. Taste is key to making sure people regularly take their medications and is an important part of drug development.
Pharmacology - Health - 21.09.2023 
Salting less could prevent 5,300 deaths a year in Canada
This figure represents around 9% of deaths caused by cardiovascular disease in Canada each year. Reducing our salt intake to the level recommended by public health authorities could prevent up to 5,300 deaths per year in Canada. This is the conclusion reached by a research team at the end of a study evaluating the impact of different scenarios for reducing sodium consumption on the health of the Canadian population.
Health - Pharmacology - 21.09.2023 
Small cell lung cancer: new approach to overcoming chemo-resistance
Small cell lung cancer accounts for about 15 percent of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumours often develop resistance to chemotherapy and thus poor prognosis is due to tumour recurrence which occurs within only five to 14 months after initial diagnosis.
Health - Pharmacology - 21.09.2023
Health - Pharmacology - 20.09.2023
Health - Pharmacology - 20.09.2023 
Convalescent plasma treatment may lower long COVID risk
Early convalescent plasma treatment may lower long COVID risk, study finds Review of long-term outcomes finds the use of plasma from recovered COVID patients, helpful in preventing severe COVID, could also decrease likelihood of post-COVID symptoms Findings from a nationwide, multicenter study led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health suggest that patients with COVID-19 have less chance of developing p
Health - Pharmacology - 19.09.2023 
Testing for long Covid: Eye exam as a new approach - TUM
Blood vessels in the eye altered with persistent coronavirus symptoms New approach to testing for long Covid A standardized eye examination might reveal in future whether people are suffering from long Covid syndrome or post-Covid. A team at the Technical University of Munich (TUM) was able to demonstrate a clear connection between the disease and certain changes to the blood vessels in the eye.
Pharmacology - Health - 19.09.2023 
Drug Delivery Platform Uses Sound for Targeting
Chemotherapy as a treatment for cancer is one of the major medical success stories of the 20th century, but it's far from perfect. Anyone who has been through chemotherapy or who has had a friend or loved one go through it will be familiar with its many side effects: hair loss, nausea, weakened immune system, and even infertility and nerve damage.
Health - Pharmacology - 19.09.2023 
An implantable device could enable injection-free control of diabetes
The device contains encapsulated cells that produce insulin, plus a tiny oxygen-producing factory that keeps the cells healthy. One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections.
Health - Pharmacology - 18.09.2023
Pharmacology
Results 1 - 20 of 381.
A European research team led by the Department of Chemistry at Universität Hamburg presents a study showing high-resolution structures of 17 distinct antibiotic ribosomal compounds. The knowledge could pave the way for the development of new antibiotics to combat multidrug-resistant bacteria. The results were published in the journal Nature Structural & Molecular Biology.
Researchers at ETH Zurich have developed a suction cup that allows medications to be absorbed through the mucosal lining of the cheeks. This new approach could spare millions of patients the pain and fear associated with injections. Many of today's medications belong to groups of relatively large molecules such as peptides.
Protein that drives liver damage could be a new target for treatment
Yale researchers have identified a protein that drives symptoms of severe liver disease and may be a target for treatment in the future. A severe form of fatty liver disease called nonalcoholic steatohepatitis (NASH) is the leading cause of liver transplantation, but there are few treatment options and currently no medications.
Yale researchers have identified a protein that drives symptoms of severe liver disease and may be a target for treatment in the future. A severe form of fatty liver disease called nonalcoholic steatohepatitis (NASH) is the leading cause of liver transplantation, but there are few treatment options and currently no medications.
Protein that drives liver damage could be a target for treatment
Yale researchers have identified a protein that drives symptoms of severe liver disease and may be a target for treatment in the future. A severe form of fatty liver disease called nonalcoholic steatohepatitis (NASH) is the leading cause of liver transplantation, but there are few treatment options and currently no medications.
Yale researchers have identified a protein that drives symptoms of severe liver disease and may be a target for treatment in the future. A severe form of fatty liver disease called nonalcoholic steatohepatitis (NASH) is the leading cause of liver transplantation, but there are few treatment options and currently no medications.
An advance in cryo-EM could be a significant boon for research on potential cancer therapies Science + Technology An advance in cryo-EM could be a significant boon for research on potential cancer therapies September 26, 2023 Key takeaways A technology called cryo-electron microscopy, or cryo-EM, enables scientists to see the atomic structure of biological molecules in high resolution.
Imperial and US medical technology company MediBeacon have partnered to advance a non-invasive method of assessing intestinal health. In healthy people, the wall of the intestine forms a barrier between the contents of the gut and the rest of the body, with only the nutrients produced by digestion passing through.
New vaccine technology could protect from future viruses and variants
Studies of a 'future-proof' vaccine candidate have shown that just one antigen can be modified to provide a broadly protective immune response in animals. The studies suggest that a single vaccine with combinations of these antigens - a substance that causes the immune system to produce antibodies against it - could protect against an even greater range of current and future coronaviruses.
Studies of a 'future-proof' vaccine candidate have shown that just one antigen can be modified to provide a broadly protective immune response in animals. The studies suggest that a single vaccine with combinations of these antigens - a substance that causes the immune system to produce antibodies against it - could protect against an even greater range of current and future coronaviruses.
Molnupiravir, an antiviral drug used to treat patients with COVID-19, appears to be driving SARS-CoV-2 to mutate and evolve, with some of these new viruses being transmitted onwards, a new study has shown. It is not clear, however, whether these mutated viruses pose an increased risk to patients or are able to evade the vaccine.
Brain imaging tool falls short for human tissue
A common research tool used to measure brain inflammation and test new dementia drugs may not be as helpful as scientists had hoped. In clinical research, scientists use a type of imaging called positron emission tomography (PET) to gain a detailed view of what's happening in the brain. One of the markers targeted by scans, called translocator protein (TSPO), has long been used to measure inflammation driven by microglia - the specialised immune cells in the brain which respond to damage and disease.
A common research tool used to measure brain inflammation and test new dementia drugs may not be as helpful as scientists had hoped. In clinical research, scientists use a type of imaging called positron emission tomography (PET) to gain a detailed view of what's happening in the brain. One of the markers targeted by scans, called translocator protein (TSPO), has long been used to measure inflammation driven by microglia - the specialised immune cells in the brain which respond to damage and disease.
Could this new hydrogel make HIV therapy more convenient? A new injectable solution that self-assembles into a gel under the right conditions could help manage HIV unlike any currently available methods, Johns Hopkins researchers have found A new injectable solution that self-assembles into a gel under the right conditions could help manage HIV unlike any currently available methods, researchers have found.
A team from the UCL Global Business School for Health (GBSH) and the UCL School of Pharmacy are using data collected from an "electric tongue" to create an AI model for predicting the bitterness of drugs. Taste is key to making sure people regularly take their medications and is an important part of drug development.
This figure represents around 9% of deaths caused by cardiovascular disease in Canada each year. Reducing our salt intake to the level recommended by public health authorities could prevent up to 5,300 deaths per year in Canada. This is the conclusion reached by a research team at the end of a study evaluating the impact of different scenarios for reducing sodium consumption on the health of the Canadian population.
Small cell lung cancer accounts for about 15 percent of all diagnosed lung cancers and is still associated with a high mortality rate. SCLC tumours often develop resistance to chemotherapy and thus poor prognosis is due to tumour recurrence which occurs within only five to 14 months after initial diagnosis.
New target to beat cancer drug resistance
University of Queensland researchers have identified a novel drug target with the potential to overcome drug resistance and prevent tumour regrowth in cancer patients. Associate Professor Helmut Schaider from UQ's Frazer Institute said the newly identified molecule was not currently a target for treatment, opening the potential for drug development.
University of Queensland researchers have identified a novel drug target with the potential to overcome drug resistance and prevent tumour regrowth in cancer patients. Associate Professor Helmut Schaider from UQ's Frazer Institute said the newly identified molecule was not currently a target for treatment, opening the potential for drug development.
Strengthening artificial immune cells to fight cancer
Scientists in Western Switzerland have discovered how to improve the anti-tumour power of CAR-T cells, artificial immune ''super-cells'' used against blood cancers. Among available immunotherapies, the use of 'CAR-T' cells is proving extremely effective against certain blood cancers, but only in half of patients.
Scientists in Western Switzerland have discovered how to improve the anti-tumour power of CAR-T cells, artificial immune ''super-cells'' used against blood cancers. Among available immunotherapies, the use of 'CAR-T' cells is proving extremely effective against certain blood cancers, but only in half of patients.
Early convalescent plasma treatment may lower long COVID risk, study finds Review of long-term outcomes finds the use of plasma from recovered COVID patients, helpful in preventing severe COVID, could also decrease likelihood of post-COVID symptoms Findings from a nationwide, multicenter study led by Johns Hopkins Medicine and the Johns Hopkins Bloomberg School of Public Health suggest that patients with COVID-19 have less chance of developing p
Blood vessels in the eye altered with persistent coronavirus symptoms New approach to testing for long Covid A standardized eye examination might reveal in future whether people are suffering from long Covid syndrome or post-Covid. A team at the Technical University of Munich (TUM) was able to demonstrate a clear connection between the disease and certain changes to the blood vessels in the eye.
Chemotherapy as a treatment for cancer is one of the major medical success stories of the 20th century, but it's far from perfect. Anyone who has been through chemotherapy or who has had a friend or loved one go through it will be familiar with its many side effects: hair loss, nausea, weakened immune system, and even infertility and nerve damage.
The device contains encapsulated cells that produce insulin, plus a tiny oxygen-producing factory that keeps the cells healthy. One promising approach to treating Type 1 diabetes is implanting pancreatic islet cells that can produce insulin when needed, which can free patients from giving themselves frequent insulin injections.
Autoimmune diseases: Protein discovered as potential new target for therapies
Autoimmune diseases are complex illnesses, the causes of which are diverse and have not yet been fully explained. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. The identified component of the immune system is called "Rinl", which could provide a new target for the development of immunomodulatory therapies.
Autoimmune diseases are complex illnesses, the causes of which are diverse and have not yet been fully explained. A research team at MedUni Vienna has now discovered an immunoregulatory protein that could be linked to the development of autoimmune diseases such as rheumatoid arthritis. The identified component of the immune system is called "Rinl", which could provide a new target for the development of immunomodulatory therapies.
