news

A new study led by researchers from Trinity and the Moffitt Cancer Center shows how radiation therapy can be used to expose-and then eliminate-therapy-resistant cancer cells using natural killer cell immunotherapy. Many patients with metastatic cancers receive therapy that is initially highly effective, often resulting in complete remission.

New Trinity study is first of its kind in Ireland to specifically focus on women to address the disproportionately poor physical health of this population when compared to the general population. A study published by Trinity College researchers from the School of Medicine in the journal BMJ Open , explored the effect of an exercise programme in a Dublin day centre for women who are dealing with challenging issues.

Researchers believe this study further highlights that a key immune system switch warrants full investigation in MS and may be a promising potential target for future MS therapies. Trinity College Dublin researchers have published a new study on MS that has uncovered evidence that a key immune system switch, known as the NLRP3 inflammasome, may play a significant role in the inflammatory processes associated with the pathogenesis of MS.

Posted on: 19 December 2025 The team has uncovered that the Irish Cervical Cancer Screening programme has prevented over 5500 cancers in Ireland, that would over wise have occurred in the lifetime of women screened. The outcomes figured by the team give a solid support for the clear efficacy of cervical cancer screening in Ireland and beyond.

Posted on: 02 December 2025 Trinity researchers have led a new collaborative study, combining large genetic datasets with satellite weather data and uncovering over 30 distinct genes that influence vitamin D status, many of which were not previously known. The study involved collaborators from Maynooth University, the Netherlands, UK, Denmark, Austria, and Germany and is published in the journal Nature Communications.

Posted on: 26 November 2025 The scientists have discovered that a single inherited mutation causes whole-body issues in a model of inherited primary mitochondrial disorders after the immune response is sparked into action. Although the scientists stress the research is at a relatively early stage, it is one of the first pieces of work to show that a heritable mitochondrial DNA mutation can independently remodel immune cell function and inflammatory signalling.

Posted on: 14 November 2025 A comprehensive programme of new research from the Health Research Board (HRB) Collaborative Doctoral Award (CDA) in Multimorbidity has provided crucial insights and evidence-based solutions to improve healthcare and outcomes for people living with multiple long-term conditions (multimorbidity).

Posted on: 11 November 2025 An international study led by Agustín Ibáñez and co-authors reveals that speaking multiple languages may slow the biological processes of aging and protect against age-related decline. Multilingualism protects against accelerated aging in cross-sectional and longitudinal analyses of 27 European countries Can learning another language help you stay younger for longer?

Posted on: 31 October 2025 Two landmark international studies led by Professor Ignacio Martin-Loeches have been recently published in The Lancet and Nature Medicine - placing Irish critical care research firmly on the global stage.

Posted on: 23 October 2025 Researchers wanted to know what allows the infection to hang on or come back, and whether it develops new tricks or resistances while living inside the lungs. Researchers at Trinity Translational Medicine Institute (TTMI) and the Irish Mycobacterial Reference Laboratory at St James's Hospital have uncovered how the bacterium Mycobacterium avium -a leading cause of difficult-to-treat chronic lung infections -changes and adapts inside patients over many years of illness.

Posted on: 22 October 2025 Researchers from Trinity College, St Patrick's Mental Health Services, Queen's University Belfast, Ireland, investigate use of twice-weekly ketamine infusions as an add-on treatment for inpatients with serious depression Findings from a randomised and blinded clinical trial investigating repeated ketamine infusions for treating depression have revealed no extra benefit for ketamine when added onto standard care for people admitted to hospital for depression.

Posted on: 09 October 2025 Researchers wanted to understand how steroids selectively affect human macrophages, which are a key cellular player in the immune response to Mycobacterium tuberculosis (Mtb); the bacteria which causes TB. Tuberculosis (TB) remains a major global health challenge, affecting over 10 million people annually worldwide, with 1.25 million people dying of TB every year.

Posted on: 03 October 2025 Engaging in creative experiences like music, dance, visual arts, and even specific video games can slow brain aging and promote healthier brain function, says a trailblazing international GBHI study from published in Nature Communications Although creativity has long been celebrated for its cultural and personal value, this study is the first large-scale scientific evidence directly linking creative engagement to direct measurable protection of brain health.

Posted on: 15 September 2025 Scientists from the Trinity Biomedical Sciences Institute (TBSI) have discovered how nanoplastics - even smaller than microplastics - disrupt energy metabolism in brain cells. Their findings may have implications for better understanding neurodegenerative diseases characterised by declining neurological or brain function, and even shed new light on issues with learning and memory.

Posted on: 12 September 2025 Parents report improvements in physical activity, social engagement and family life in their children in the first qualitative assessment of its type led by researchers from Trinity. This study provides important evidence in an area of growing therapeutic interest. Specifically, the parents of 10 children aged 6-12 with neurological and/or physical impairments in their walking perceived improvements in most of the childrens' physical activity levels, as well as in their social engagement and family life.

Posted on: 09 September 2025 The Irish Longitudinal Study on Ageing (TILDA) has released its 'Wave 6' findings which points to challenging times for Ireland's older population. Ireland is one of the fastest ageing countries in Europe, with the population aged 65 and over projected to double by 2051.

Posted on: 08 September 2025 An early phase clinical trial published in Nature Medicine show that patients with mesothelioma - a rare cancer of the lining of the lung - who received a combination of two immunotherapy drugs before surgery had successful surgeries and encouraging early outcomes Results from an early phase clinical trial presented this week at the World Conference on Lung Cancer Meeting in Barcelona, Spain, and published in Nature

Posted on: 02 September 2025 Scientists from Trinity have discovered that electrically stimulating "macrophages" - one of the immune system's key players - can "reprogramme" them in such a way to reduce inflammation and encourage faster, more effective healing in disease and injury. This breakthrough uncovers a potentially powerful new therapeutic option, with further work ongoing to delineate the specifics.

Scientists discover how genetic mutations drive Weaver syndrome, with implications for overgrowth disorders and cancer risk Scientists have discovered how mutations in a specific gene drive the rare developmental disorder Weaver syndrome, which is marked by intellectual disability and overgrowth and predisposes people with the condition to cancer.

Mutations in a single gene are the driving factor behind Weaver syndrome, a rare disorder associated with overgrowth, intellectual disability, and higher cancer risk. In a co-lead study between University College Dublin and Trinity College Dublin, researchers uncovered how mutations in the EZH2 gene upsets critical cellular processes.